Review



hdac substrate peptide ac arg gly lys ac glu amc  (Elim Bio)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 86
      Buy from Supplier

    Structured Review

    Elim Bio hdac substrate peptide ac arg gly lys ac glu amc
    (A) Superposition of human <t>HDAC(1-11)</t> structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.
    Hdac Substrate Peptide Ac Arg Gly Lys Ac Glu Amc, supplied by Elim Bio, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hdac+substrate+peptide+ac+arg+gly+lys+ac+glu+amc/ac+ac+amc+arg+glu+gly+hdac+lys+peptide+substrate/bio_rxiv__64898__2026__01__26__701829-258-24-31
    Average 86 stars, based on 1 article reviews
    hdac substrate peptide ac arg gly lys ac glu amc - by Bioz Stars, 2026-10
    86/100 stars

    Images

    1) Product Images from "A small molecule PTER-selective inhibitor reduces food intake and body weight"

    Article Title: A small molecule PTER-selective inhibitor reduces food intake and body weight

    Journal: bioRxiv

    doi: 10.64898/2026.01.26.701829

    (A) Superposition of human HDAC(1-11) structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.
    Figure Legend Snippet: (A) Superposition of human HDAC(1-11) structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.

    Techniques Used: Labeling, Inhibition, Activity Assay, Recombinant, Purification

    Related Articles

    Histone Deacetylase Assay:

    Article Title: A small molecule PTER-selective inhibitor reduces food intake and body weight
    Article Snippet: The supernatant protein concentration was determined using a Nanodrop One. .. The HDAC assay was performed in 50 μl reaction volume containing the HDAC reaction assay buffer, 600 μg of the liver lysate, 100 μM HDAC substrate peptide Ac-Arg-Gly-Lys-Ac-Glu-AMC (custom synthesized by Elim Biopharm), and 10 μM of indicated inhibitors. ..

    Synthesized:

    Article Title: A small molecule PTER-selective inhibitor reduces food intake and body weight
    Article Snippet: The supernatant protein concentration was determined using a Nanodrop One. .. The HDAC assay was performed in 50 μl reaction volume containing the HDAC reaction assay buffer, 600 μg of the liver lysate, 100 μM HDAC substrate peptide Ac-Arg-Gly-Lys-Ac-Glu-AMC (custom synthesized by Elim Biopharm), and 10 μM of indicated inhibitors. ..



    Similar Products

    hdac substrate peptide ac arg gly lys ac glu amc  (Elim Bio)
    86
    Elim Bio hdac substrate peptide ac arg gly lys ac glu amc
    (A) Superposition of human <t>HDAC(1-11)</t> structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.
    Hdac Substrate Peptide Ac Arg Gly Lys Ac Glu Amc, supplied by Elim Bio, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hdac+substrate+peptide+ac+arg+gly+lys+ac+glu+amc/ac+ac+amc+arg+glu+gly+hdac+lys+peptide+substrate/bio_rxiv__64898__2026__01__26__701829-258-24-31
    Average 86 stars, based on 1 article reviews
    hdac substrate peptide ac arg gly lys ac glu amc - by Bioz Stars, 2026-10
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Superposition of human HDAC(1-11) structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.

    Journal: bioRxiv

    Article Title: A small molecule PTER-selective inhibitor reduces food intake and body weight

    doi: 10.64898/2026.01.26.701829

    Figure Lengend Snippet: (A) Superposition of human HDAC(1-11) structures showing conserved aromatic side chains in active site. Average distance between two side chain is labeled. PDB IDs are 4BKX, 4LXZ, 4A69, 2VQJ, 5EDU, 3C0Y, 1T64 for human HDAC 1-4, 6-8. HDAC5 and 9-11 are AlphaFold-predicted models. The representative SAHA (white) is from an HDAC2 co-crystal structure (PDB ID 4LXZ). (B) Superposition of the top poses of docked PTERi (yellow) in sPTER and docked SAHA in sPTER, and SAHA from an HDAC2 co-crystal structure (PDB ID 4LXZ). Superposition is based on the top-ranked SAHA pose in sPTER and SAHA pose in HDAC2. SAHA poses are not shown for simplicity. Side chains of sPTER are shown in purple, while side chains of HDAC2 are shown in white. (C) Chemical structure of PTERi. (D) Dose-response inhibition of PTER activity by PTERi. (E) Heat map of dose-response inhibition for PTERi against the indicated recombinant enzyme. (F, G) Lineweaver-Burke plot (F) and dose-response inhibition of PTERi (G) in PTER activity assays. For (D-G) , PTER activity (N-acetyltaurine hydrolysis) was measured by quantifying taurine production using 200 ng of purified recombinant mouse PTER (mPTER, panels D-G ) or purified recombinant PTER from the indicated species (G) and 100 µM N-acetyltaurine for 1 h at 37°C. N=3/data point for (D,G) and N=1/data point for (E,F) . (D,G) are shown as mean ± SEM. IC 50 values for were determined from the dose-response curves via nonlinear regression analysis using GraphPad Prism.

    Article Snippet: The HDAC assay was performed in 50 μl reaction volume containing the HDAC reaction assay buffer, 600 μg of the liver lysate, 100 μM HDAC substrate peptide Ac-Arg-Gly-Lys-Ac-Glu-AMC (custom synthesized by Elim Biopharm), and 10 μM of indicated inhibitors.

    Techniques: Labeling, Inhibition, Activity Assay, Recombinant, Purification